反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (53 mg) was dissolved in toluene (5 ml) with heat, 3-ethoxycarbonylphenyl isocyanate (284 mg) was added, and the admixture was refluxed with heat for 1 hour. The resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 18 mg of the title compound (yield: 20%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 1 hour
4. customThe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1)