反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (83 mg) was dissolved in toluene (6 ml) with heat, 3-nitrophenyl isocyanate (384 mg) was added, and the admixture was refluxed with heat for 40 minutes. The resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 44 mg of the title compound (yield: 34%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 40 minutes
4. customThe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1)