反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (52 mg) was dissolved in toluene (5 ml) with heat, ethoxycarbonyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 15 minutes. The resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 20 mg of the title compound (yield: 28%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 15 minutes
4. customThe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1)