4-Aminobenzophenone → HCID 22132709, compound

Participants

Reaction Steps

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (54 mg) was suspended in toluene (5 ml), triphosgene (53 mg) was added, and the admixture was refluxed with heat for 20 minutes. 4-Aminobenzophenone (85 mg) was added to the reaction mixture, and the admixture was refluxed for 1 hour with heat. After the addition of aqueous sodium hydrogen carbonate, the reaction mixture was extracted 2 times with ethyl acetate, and the organic layer was then washed with brine and dried with anhydrous sodium sulfate. The solvent was removed by reduced-pressure distillation and the resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 19 mg of the title compound (yield: 21%).

Provenance & Evidence