Sodium methanethiolate → 2-Trifluoromethylphenyl 4-hydroxyphenyl ketone

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Reaction Steps

2-Trifluoromethylphenyl 4-methoxyphenyl ketone (1.402 g) obtained in Example 144 was dissolved in N,N-dimethylformamide (15 ml), sodium thiomethoxide (877 mg) was added, and the admixture was refluxed with heat for 4 hours under argon. The reaction mixture was treated in the same manner as described in Example 33 to obtain 1.050 g of the title compound (yield: 79%).

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