反应详情

温度

60 °C

To commercially available nitromethane (5 ml) were added commercially available anisole (541 mg), commercially available 3-fluorobenzoyl chloride (793 mg) and commercially available scandium(III) trifluoromethanesulfonate (49 mg), and the admixture was stirred at 60° C. for 3 days. The reaction mixture was partitioned between water and chloroform, and the chloroform layer was then dried with anhydrous magnesium sulfate. After removing the solvent by reduced-pressure distillation, the resulting residue was purified by chromatography on silica gel eluting with hexane/acetone to obtain 585 mg of the title compound (yield: 51%).

1. customThe reaction mixture was partitioned between water and chloroform
2. dry with materialthe chloroform layer was then dried with anhydrous magnesium sulfate
3. customAfter removing the solvent
4. distillationby reduced-pressure distillation
5. customthe resulting residue was purified by chromatography on silica gel eluting with hexane/acetone