Anisole → (3-Fluorophenyl)(4-methoxyphenyl)methanone

HRID 1857218노트

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HRID 1857218 반응식
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13](Cl)=[O:14]>FC(F)(F)S([O-])(=O)=O.[Sc+3].FC(F)(F)S([O-])(=O)=O.FC(F)(F)S([O-])(=O)=O.[N+](C)([O-])=O>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][C:4]([C:13]([C:12]2[CH:16]=[CH:17][CH:18]=[C:10]([F:9])[CH:11]=2)=[O:14])=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 7519AnisoleHCID 743763-Fluorobenzoyl chloride

생성물 1

HCID 13467539(3-Fluorophenyl)(4-methoxyphenyl)methanone수율 51%

시약·촉매·용매 2

HCID 2734571Scandium(III) triflate촉매HCID 6375Nitromethane용매

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온도
60 °C

실험 절차

To commercially available nitromethane (5 ml) were added commercially available anisole (541 mg), commercially available 3-fluorobenzoyl chloride (793 mg) and commercially available scandium(III) trifluoromethanesulfonate (49 mg), and the admixture was stirred at 60° C. for 3 days. The reaction mixture was partitioned between water and chloroform, and the chloroform layer was then dried with anhydrous magnesium sulfate. After removing the solvent by reduced-pressure distillation, the resulting residue was purified by chromatography on silica gel eluting with hexane/acetone to obtain 585 mg of the title compound (yield: 51%).

후처리

  1. customThe reaction mixture was partitioned between water and chloroform
  2. dry with materialthe chloroform layer was then dried with anhydrous magnesium sulfate
  3. customAfter removing the solvent
  4. distillationby reduced-pressure distillation
  5. customthe resulting residue was purified by chromatography on silica gel eluting with hexane/acetone

출처 및 근거

ORD 기록
ord-bf21a0ae195f4721a01698e68db57cfc
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

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