Boron tribromide → (3-Fluorophenyl)(4-hydroxyphenyl)methanone

HRID 1857219노트

반응식

HRID 1857219 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)=[O:10])=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[F:17][C:13]1[CH:12]=[C:11]([C:9]([C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:8][CH:7]=2)=[O:10])[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 13467539(3-Fluorophenyl)(4-methoxyphenyl)methanone

생성물 1

HCID 11356363(3-Fluorophenyl)(4-hydroxyphenyl)methanone수율 74%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

3-Fluorophenyl 4-methoxyphenyl ketone (580 mg) obtained in Example 150 was dissolved in dichloromethane (5 ml), a solution of 1.0 M boron tribromide in dichloromethane (23 ml) was added while cooled in ice, and the admixture was stirred at room temperature for 3 days. The reaction mixture was treated in the same manner as described in 121 to obtain 402 mg of the title compound (yield: 74%).

후처리

  1. temperaturewhile cooled in ice
  2. additionThe reaction mixture was treated in the same manner

출처 및 근거

ORD 기록
ord-702d333414b7469a9e3268e7c8dad318
출처 데이터셋
uspto-grants-2000_11
특허 번호
US06143764

반응 노트

불러오는 중…