HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isocyanato-4-methoxybenzene → N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-(4-methoxyphenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isocyanato-4-methoxybenzene | HCID 79443 | — |
| Reactant | 4-(6,7-Dimethoxyquinazolin-4-yloxy)aniline | HCID 11616363 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-(4-methoxyphenyl)urea | HCID 11155047 | 49% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinazoline (81 mg) was dissolved in toluene (5 ml) with heat, 4-methoxyphenyl isocyanate (0.29 ml) was added, and the admixture was refluxed with heat for 40 minutes. The separated solid was filtered and washed with toluene to obtain 60 mg of the title compound (yield: 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-6c9738838f014f28a52d2493c15d46d3 |
| Source note | uspto-grants-2000_11 |