反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinazoline (100 mg) was dissolved in toluene (10 ml) with heat, 2-fluorophenyl isocyanate (0.30 ml) was added, and the admixture was refluxed with heat for 40 minutes. The separated solid was filtered and washed with toluene to obtain 96 mg of the title compound (yield: 66%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 40 minutes
4. filtrationThe separated solid was filtered
5. washwashed with toluene