反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (52 mg) was dissolved in toluene (5 ml) with heat, 2-chloro-6-methylphenyl isocyanate (0.1 ml) was added, and the admixture was refluxed with heat for 17 minutes. The separated crystals were filtered and then washed with toluene to obtain 61 mg of the title compound (yield: 74%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 17 minutes
4. filtrationThe separated crystals were filtered
5. washwashed with toluene