HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloro-3-isocyanatobenzene → HCID 11237059, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloro-3-isocyanatobenzene | HCID 33050 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 11237059 | HCID 11237059 | 100% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (52 mg) was dissolved in toluene (5 ml) with heat, 2,3-dichlorophenyl isocyanate (0.05 ml) was added, and the admixture was refluxed with heat for 20 minutes. The reaction solution was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 84 mg of the title compound (yield: 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-48e63540f8d942a09a050619efa95a65 |
| Source note | uspto-grants-2000_11 |