反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (58 mg) was dissolved in toluene (5 ml) with heat, 2,4-dichlorophenyl isocyanate (93 mg) was added, and the admixture was refluxed with heat for 20 minutes. The reaction solution was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 69 mg of the title compound (yield: 73%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 20 minutes
4. customThe reaction solution was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1)