HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-chloro-5-isocyanato-2,4-dimethoxybenzene → HCID 22132654, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-chloro-5-isocyanato-2,4-dimethoxybenzene | HCID 4389804 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 22132654 | HCID 22132654 | 100.1% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (54 mg) was dissolved in toluene (5 ml) with heat, 3-chloro-4,6-dimethoxyphenyl isocyanate (76 mg) was added, and the admixture was refluxed with heat for 18 minutes. The reaction solution was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 93 mg of the title compound (yield: 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-78f317a475ab49a0827e6181d9bb5507 |
| Source note | uspto-grants-2000_11 |