3-Aminophenol → HCID 22132761, compound

Participants

Reaction Steps

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (115 mg) was dissolved in toluene (12 ml) with heat, after the addition of triethylamine (2 ml), triphosgene (113 mg) was added, and the admixture was refluxed with heat for 2 minutes. 3-Aminophenol (73 mg) was added to the reaction mixture, and the admixture was refluxed with heat for 10 minutes. After the addition of aqueous sodium hydrogen carbonate, the reaction mixture was extracted with chloroform, and the organic layer was then washed with brine and dried with anhydrous sodium sulfate. The solvent was removed by reduced-pressure distillation, and the resulting residue was washed with chloroform and filtered to obtain 95 mg of the title compound (yield: 60%).

Provenance & Evidence