反应详情

N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea (190 mg) obtained in Example 197 was dissolved in methanol (3 ml), 35% aqueous potassium hydroxide (5 ml) was added, and the admixture was stirred at room temperature for 30 minutes. After removing methanol by reduced-pressure distillation and neutralizing using dilute hydrochloric acid, the separated crystals were filtered to obtain 67 mg of the title compound (yield: 38%).

1. customAfter removing methanol
2. distillationby reduced-pressure distillation
3. filtrationthe separated crystals were filtered