反应详情

To 3.00 g of methyl 3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoate were added 10 ml of ethanol and 20 ml of a 1N sodium hydroxide solution to stir at room temperature for 2 days. Ethanol was distilled out under reduced pressure. The remaining solution was acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, then with a saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was distilled out under reduced pressure to give 2.75 g of the title compound as white crystals. m.p. 182~184.5° C.

1. distillationEthanol was distilled out under reduced pressure
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialwith a saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
5. distillationThe solvent was distilled out under reduced pressure