Benzyl Bromide → HCID 15477455, compound

Participants

Reaction Steps

0.45 g of 4-[3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoyl]-5-hydroxy-1-methylpyrazole was dissolved in 15 ml of DMF, and 0.26 g of potassium carbonate, then 0.25 g of benzyl bromide were added. The resulting solution was stirred at room temperature overnight. The reaction solution was poured into ice water, and extracted with ethyl acetate. The organic layer was washed with water, then with a saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was distilled out under reduced pressure. Methanol was added to the residue. The obtained crystals were separated by filtration to give 0.42 g of the title compound as white crystals. m.p. 151.5~153° C.

Provenance & Evidence