反应详情

To a solution of 15.1 g (58.1 mmol) of 3-chloro-2,4-difluoro-(trifluoroacetamido)-benzene in 80 mL of H2SO4 kept in an ice-bath was added dropwise 10 mL of HNO3. Solid precipitate was observed during addition of HNO3. The mixture was stirred in an ice-bath for 4 h, then added to 600 mL of ice-water. The precipitate was filtered, washed with water, and dried to leave an almost colorless solid (16.8 g, 95%); mp 124-125° C.; 1H NMR (CDCl3), 7.69 (dd, 1), 8.936 (mb, 1).

1. filtrationThe precipitate was filtered
2. washwashed with water
3. customdried