4-Pyridineethanamine → HCID 9887274, compound

HRID 1857462Notes

Reaction equation

[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([NH:13][C:14](=[N:22][C:23]#[N:24])OC2C=CC=CC=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH2:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=1>>[C:23]([NH:22][C:14]([NH:13][C:5]1[CH:6]=[C:7]([C:9]([F:11])([F:10])[F:12])[CH:8]=[C:3]([C:2]([F:26])([F:1])[F:25])[CH:4]=1)=[N:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=1)#[N:24]

Participants

Reactant 2

HCID 832754-Pyridineethanamine

HCID 178512266HCID 178512266, compound

Product 1

HCID 9887274HCID 9887274, compoundYield 27.4%

Procedure

By following a procedure analogous to the one described in EXAMPLE 1b, N-(3,5-bis(trifluoromethyl)-phenyl)-N'-cyano-O-phenylisourea (1 mmol, 373 mg) was treated with 4-(2-aminoethyl)pyridine (1.15 mmol, 140.5 mg) to give 110 mg (27%) of the title product;

Sources & evidence

ORD record: ord-ec7f559c27874248b6f8ae1a1e4f4b12
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06147098

Reaction notes

Loading…