Cyclopentylamine → HCID 9841980, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of N-(3,5-bis(trifluoromethyl)phenyl)-N'-cyano-O-phenylisourea (0.400 g, 1.1 mmol) in dry acetonitrile (2.5 ml) triethylamine (0.164 ml, 1.2 mmol) and cyclopentylamine (0.116 ml, 1.2 mmol) was added. The homogenous solution was stirred at 85° C. under N2 for 3.5 h. The solvent was evaporated, and the residue was dissolved in ethyl acetate and washed with water twice. The organic layer was dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography using ethyl acetate/heptane 1:2 to give the title compound. Yield 82% (0.320 g). mp 156-159° C.

Provenance & Evidence