Isoamylamine → HCID 11197309, compound

Participants

Reaction Conditions

Reaction Steps

To N-(3,5-Dichlorophenyl)-N'-cyano-O-phenylisourea (0.98 mmol, 300 mg) in dry acetonitrile (2 ml), 3-methylbutylamine (2.16 mmol, 0.255 ml) and triethylamine (1.08 mmol, 0.150 ml) were added. The reaction mixture was stirred for 16 h at 85° C. under nitrogen. The precipitated material was filtered off and recrystallized from ethyl acetate to give the title compound (160 mg, 54%) as white crystals. Mp 146.5-1451.5° C.; 1H-NMR (CDCl3): δ 0.94 (d, 6H), 1.43 (q, 2H), 1.6 (m, 1H), 3.31 (q, 2H), 4.9 (br, 1H), 7.18 (br s, 2H), 7.29 (br s, 1H), 7.5 ppm (br, 1H); MA calc for C13H16Cl2N4 : C, 52.19%; H, 5.39%; N, 18.73%. Found: C, 52.23%; H, 5.51%; N, 18.60%.

Provenance & Evidence