反应详情

A mixture of (E)-4-[2-[5-methyl-2-(3-methylphenyl)-4-oxazolyl]ethoxy]cinnamaldehyde (1.20 g), 2,4-oxazolidinedione (0.525 g), piperidine (0.09 g) and ethanol (20 ml) was heated for 5 hours under reflux. The reaction mixture was poured into water, which was acidified with 2N HCl, followed by extraction with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4) and, then, concentrated. The concentrate was purified by means of a silica gel column chromatography. From the fractions eluted with chloroform-methanol (50:1) was obtained 5-[4-[2-[5-methyl-2-(3-methylphenyl)-4-oxazolyl]ethoxy]cinnamylidene]-2,4-oxazolidinedione (0.51g, 34%). Recrystallization from dichloromethane-methanol gave pale yellow prisms, m.p.213-214° C.

1. temperaturewas heated for 5 hours
2. temperatureunder reflux
3. extractionfollowed by extraction with ethyl acetate
4. washThe ethyl acetate layer was washed with water
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. customThe concentrate was purified by means of a silica gel column chromatography
8. washFrom the fractions eluted with chloroform-methanol (50:1)