(3-Bromophenyl)acetyl chloride → 2-[2-(3-Bromophenyl)-acetylamino]-4-chloro-5-nitrobenzoic acid methyl ester

Beteiligte Stoffe

Reaktionsschritte

To a suspension of 2-amino-4-chloro-5-nitrobenzoic acid methyl ester (Example 9, 780 mg in 10 mL dichloroethane) was added a solution of (3-bromophenyl)acetyl chloride (prepared essentially as described in Example 9, 866 mg in 5 mL dichloroethane) and the mixture heated to reflux on an oil bath. After 18 hours, the reaction mixture was concentrated in vacuo and the title compound obtained by crystallization from methanol (1.18 g).

Herkunft & Nachweise