反应详情

To a solution of 2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-nitro-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester (100 mg in 3.5 mL N,N-dimethylformamide) at 0° C. was added 7.6 mg sodium hydride and the mixture stirred for 1 hour at low temperature. At this time, 0.012 mL iodomethane were added continued stirring. After 30 minutes, the reaction was quenched by the addition of saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic portion was washed with water and brine then dried over magnesium sulfate to give the crude title compound.

1. stirringcontinued stirring
2. waitAfter 30 minutes
3. customthe reaction was quenched by the addition of saturated aqueous ammonium chloride
4. extractionextracted with ethyl acetate
5. washThe organic portion was washed with water and brine
6. dry with materialthen dried over magnesium sulfate