Water → 1-Bromo-4-phenylmethoxybenzene

Participants

Reaction Steps

15.26 g of sodium hydride at 50% in oil is added at 0° C. to a solution under inert gas of 50 g of parabromophenol in 320 ml of dimethylformamide (DMF), agitation is carried out for 30 minutes at 0° C., then 37.7 ml of benzyl bromide is added. Agitation is carried out for 2 hours 30 minutes while allowing the temperature to rise to 20° C., then the reaction mixture is poured into ice-cooled water, the precipitate is filtered, and dried. 73.35 g of expected product is obtained. Rf: 0.85 (thin layer chromatography, support: silica, eluant: cyclohexane/ethyl acetate 7/3).

Provenance & Evidence