2-Azidomethyl-4-(3,5-difluorophenylthio)-1-ethyl-5-isopropyl-1h-imidazole → (5-(3,5-Dichlorophenylthio)-1-dodecyl-4-isopropyl-1H-imidazol-2-yl)methanol

HRID 1857705Notes

Reaction equation

HRID 1857705 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:13]([CH2:27][O:28]CC3C=CC(OC)=CC=3)=[N:12][C:11]=2[CH:38]([CH3:40])[CH3:39])[CH:5]=[C:6]([Cl:8])[CH:7]=1.N(CC1N(CC)C(C(C)C)=C(SC2C=C(F)C=C(F)C=2)N=1)=[N+]=[N-]>>[Cl:8][C:6]1[CH:5]=[C:4]([S:9][C:10]2[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:13]([CH2:27][OH:28])=[N:12][C:11]=2[CH:38]([CH3:39])[CH3:40])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 221303372-Azidomethyl-4-(3,5-difluorophenylthio)-1-ethyl-5-isopropyl-1h-imidazoleHCID 221310225-(3,5-Dichlorophenylthio)-1-dodecyl-4-isopropyl-2-(p-methoxybenzyloxymethyl)-1h-imidazole

Product 1

HCID 473926(5-(3,5-Dichlorophenylthio)-1-dodecyl-4-isopropyl-1H-imidazol-2-yl)methanol

Procedure

Compound I-18 was obtained from 5-(3,5-dichlorophenylthio)-1-dodecyl-4-isopropyl-2-(p-methoxybenzyloxymethyl)-1H-imidazole (17h) by the same synthetic process as that for Compound I-16 in Example 16 (yield 68%).

Sources & evidence

ORD record
ord-9154b898d4b34e2ab2a169df75a2c4ca
Source dataset
uspto-grants-2000_11
Patent number
US06147097

Reaction notes

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