2-Azidomethyl-4-(3,5-difluorophenylthio)-1-ethyl-5-isopropyl-1h-imidazole → [1-benzoylmethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1H-imidazol-2-yl]methanol

HRID 1857706Notes

Reaction equation

HRID 1857706 reaction equation
[C:1]([CH2:9][N:10]1[C:14]([S:15][C:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[CH:17]=2)=[C:13]([CH:24]([CH3:26])[CH3:25])[N:12]=[C:11]1[CH2:27][O:28]CC1C=CC(OC)=CC=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N(CC1N(CC)C(C(C)C)=C(SC2C=C(F)C=C(F)C=2)N=1)=[N+]=[N-]>>[C:1]([CH2:9][N:10]1[C:14]([S:15][C:16]2[CH:17]=[C:18]([Cl:23])[CH:19]=[C:20]([Cl:22])[CH:21]=2)=[C:13]([CH:24]([CH3:26])[CH3:25])[N:12]=[C:11]1[CH2:27][OH:28])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 221303372-Azidomethyl-4-(3,5-difluorophenylthio)-1-ethyl-5-isopropyl-1h-imidazoleHCID 221309991-Benzoylmethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-2-(p-methoxybenzyloxymethyl)-1h-imidazole

Product 1

HCID 22130138[1-benzoylmethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1H-imidazol-2-yl]methanol

Procedure

Compound I-31 was obtained from 1-benzoylmethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-2-(p-methoxybenzyloxymethyl)-1H-imidazole (17u) by the same synthetic process as that for Compound I-16 in Example 16 (yield 75%). mp 205-211° C.

Sources & evidence

ORD record
ord-1a611c7d546f464986b18ad56be715d0
Source dataset
uspto-grants-2000_11
Patent number
US06147097

Reaction notes

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