Hydrochloric Acid → HCID 54509160, compound

Participants

Reaction Steps

In a mixture of methanol (1 ml) and 6N-hydrochloric acid (1 ml) was dissolved 156 mg (0.37 mmol) of 5-(3,5-dichlorophenylthio)-2-(1,3-dioxolan-2-yloxymethyl)-4-isopropyl-1-methylimidazole (23a), and the mixture was stirred at room temperature for 3 hours. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution to neutralize, and extracted with methylene chloride. The organic layer was washed with water and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was fractionated by silica gel chromatography (ethyl acetate) to obtain 39 mg of {[5-(3,5-dichlorophenylthio)-4-isopropyl-1-methyl-1H-imidazol-2-yl]methoxy} acetaldehyde (24a) as oil (yield 28%).

Provenance & Evidence