HCID 22130341, compound → 1H-Imidazole-2-methanamine, 5-((3,5-dichlorophenyl)methyl)-1-methyl-4-(1-methylethyl)-

Participants

Reaction Steps

In 8 ml of ethanol was dissolved 150 mg (0.44 mmol) of 2-azidomethyl-5-(3,5-dichlorobenzyl)-4-isopropyl-1-methyl-1H-imidazole (60), and 50 mg of 10% palladium carbon was added at -20° C. The mixture was stirred at room temperature under a stream of hydrogen. After 4 hours, the reaction mixture was filtered through Celite, and the filtrate was concentrated to give 94 mg of Compound I-101 (yield 68%).

Provenance & Evidence