HCID 10685532, compound → HCID 18387246, compound

HRID 1857803Notes

Reaction equation

HRID 1857803 reaction equation
C[C:2]1[C:3]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:4]([C:13]([O:15]CC)=[O:14])[C:5]([C:8]([O:10]CC)=[O:9])=[N:6][CH:7]=1.C1(C2C=CN=C(C(OCC)=O)C=2C(OCC)=O)C=CC=CC=1>>[C:18]1([C:3]2[CH:2]=[CH:7][N:6]=[C:5]([C:8]([OH:10])=[O:9])[C:4]=2[C:13]([OH:15])=[O:14])[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 10685532HCID 10685532, compoundHCID 18387294HCID 18387294, compound

Product 1

HCID 18387246HCID 18387246, compound

Procedure

In place of diethyl 5-methyl-4-phenyl-2,3-pyridinedicarboxylate in Step 1 in Reference Example 33, diethyl 4-phenyl-2,3-pyridinedicarboxylate (see Japanese Patent Laid-Open No. 62-106081) was reacted and treated in the same manner as in Step 1 in Reference Exaple 33, to obtain 4-phenyl-2,3-pyridinedicarboxylic acid as pale yellow crystals. m.p. 146-148° C. (recrystallized from THF-isopropyl ether) NMR(200 MHz, CDCl3 +DMSO-d6) ppm: 7.3-7.6(6H,m), 8.69(1H,d,J=5.0 Hz)

Workup

  1. custom62-106081) was reacted
  2. additiontreated in the same manner as in Step 1 in Reference Exaple 33

Sources & evidence

ORD record
ord-d82964ab30b94dcd8cf310d983caeb92
Source dataset
uspto-grants-2000_11
Patent number
US06147071

Reaction notes

Loading…