5-Bromothiophene-2-carbaldehyde → HCID 22634675, compound

HRID 1857876Notes

Reaction equation

HRID 1857876 reaction equation
[CH3:1][C:2]1[C:3](B(O)O)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.Br[C:20]1[S:24][C:23]([CH:25]=[O:26])=[CH:22][CH:21]=1>>[CH3:1][C:2]1[C:3]([C:20]2[S:24][C:23]([CH:25]=[O:26])=[CH:22][CH:21]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1

Participants

3

Reactant 2

HCID 784285-Bromothiophene-2-carbaldehydeHCID 10037535(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronic acid

Product 1

HCID 22634675HCID 22634675, compound

Procedure

In a similar manner to Example 3(b), by reaction of 4.2 g (17 mmol) of 3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylboronic acid with 2.17 g (11.3 mmol) of 5-bromo-2-thiophenecarboxaldehyde, 2.1 g (60%) of the expected aldehyde are obtained, with a melting point of 130-5° C.

Workup

  1. customare obtained, with a melting point of 130-5° C.

Sources & evidence

ORD record
ord-b7f2970ac3764dc6b1627c31d96683d8
Source dataset
uspto-grants-2000_11
Patent number
US06147255

Reaction notes

Loading…