反应详情

温度

110 °C

A mixture of 1-chloro-3-[2-oxopyrrolidin-1-yl]propane (1.0 g, 6.2 mmol), 1-(3-chlorophenyl)piperazine (1.22 g, 6.2 minol), anhydrous Na2CO3 (0.33 g, 3.1 mmcl) and Nal (0.09~3 g, 0.6 mrnol) in dry toluene (10 ml) was stirred at 110° C. for 12 hrs. The solvent was removed at reduced pressure and residue was poured on water (20 ml). The separated residue was extracted with ethylacetate (3×20 ml), dried over Na2SO4 and concentrated under reduced pressure to give 1-[4-(3-chlorophenyl)piperazin-1-yl]-3-[2-oxopyrrolidin-1-yl]propane as an oil which was purified by flash column chromatography over silica gel using chloroform as eluent, yield 0.60 g (30.0%)

1. customThe solvent was removed at reduced pressure and residue
2. additionwas poured on water (20 ml)
3. extractionThe separated residue was extracted with ethylacetate (3×20 ml)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated under reduced pressure