Sodium Carbonate → HCID 22124621, compound

Participants

Reaction Steps

A suspension of (XIII) (1.1 g, 5.8 mmol) in 48% aqueous HBF4 (20 mL) at -10° C. was treated with NaNO2 (0.44 g, 6.38 mmol, added in small portions over 3 hours). The resulting mixture was neutralized (pH 7) with solid Na2CO3 carefully, keeping the temperature below 0° C., and extracted with EtOAc (3×75 mL). The solvent was removed, then chromatography of the residue on silica gel, eluting with ethyl acetate, gave 7-fluoro-1-ethyl-1H-[1,6]naphthyridin-2-one (XV) (0.72 g, 64%).

Provenance & Evidence