Acetic Anhydride → HCID 22124230, compound

HRID 1857967Notes

Reaction equation

HRID 1857967 reaction equation
[Cl:1][CH:2]1[C:6]([OH:11])([C:7]([F:10])([F:9])[F:8])[O:5][N:4]=[C:3]1[C:12]1[CH:17]=[C:16]([F:18])[C:15]([Cl:19])=[CH:14][C:13]=1[F:20].[C:21](OC(=O)C)(=[O:23])[CH3:22]>S(=O)(=O)(O)O>[Cl:1][CH:2]1[C:6]([O:11][C:21]([CH3:22])=[O:23])([C:7]([F:8])([F:9])[F:10])[O:5][N:4]=[C:3]1[C:12]1[CH:17]=[C:16]([F:18])[C:15]([Cl:19])=[CH:14][C:13]=1[F:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22124235HCID 22124235, compound

Product 1

HCID 22124230HCID 22124230, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Conditions

Temperature
160 °C

Procedure

One drop of concentrated sulfuric acid was added to 3.2 g of 4-chloro-3-(4'-chloro-2',5'-difluorophenyl)-5-hydroxy-5-trifluoromethylisoxazoline in 45 ml of acetic anhydride. The mixture was subsequently briefly heated to 160° C. After cooling, the reaction mixture was then concentrated under reduced pressure. The oily crude product was purified by silica gel chromatography (eluent: methylene chloride). Yield: 2.5 g; oil.

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was then concentrated under reduced pressure
  3. customThe oily crude product was purified by silica gel chromatography (eluent: methylene chloride)

Sources & evidence

ORD record
ord-73ac458dee4b4b36a71f1ffc8558699d
Source dataset
uspto-grants-2000_11
Patent number
US06150303

Reaction notes

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