Ammonia → HCID 22125505, compound

Participants

Reaction Steps

A mixture comprising ethyl 4-amino-3-phenethylaminobenzamidine hydrochloride (0.68, 2.1 mmol) and 2M ammonia in ethanol (20 mL) was heated at 90° C. in a sealed reaction container for 2.5 hours. The container was vented and the mixture was concentrated under reduced pressure to provide 4-amino-3-phenethylaminobenzamidine hydrochloride (0.4 g, 1.2 mmol) as a brown foam. 1H-NMR (300 Mhz, DMSO-d6): 2.9 (t, 2H), 3.4 (m, 2H), 5.1 (m, 1H), 5.8 (s, 2H), 6.6 (d, 1H), 6.8 (s, 1H), 7.1 (d, 1H), 7.3 (m, 5H), 8.6 (s, 2H), 8.7 (s, 2H).

Provenance & Evidence