3,4-Diaminobenzimidamide hydrochloride → HCID 178498396, compound

Participants

Reaction Steps

A mixture comprising 3,4-diaminobenzamidine hydrochloride (1.16 g, 6.2 mmol), methyl 2-(C-ethoxyiminomethyl)pyridine-4-carboxylate (1.8 g, 7.4 mmol) and anhydrous methanol (6 mL) was stirred for 20 hours. The mixture was concentrated and the residue was trituated with hot methanol (5 mL). The solid was isolated and dried to provide methyl 2-(5-amidino-1H-benzimidazol-2-yl)pyridine-4-carboxylate (1.8 g, 5.1 mmol); Calculated for C15H13N5O2 : 295.3, Found (MH+): 295.7.

Provenance & Evidence