HCID 178468754, compound → HCID 178511945, compound

Participants

Reaction Steps

A mixture comprising ethyl 6-(5-amidino-1H-benzimidazol-2-yl)pyridine-3-carboxylate (1.7 g, 5.7 mmol) and 3N hydrochloric acid (60 mL) was heated at reflux for 24 hours. The mixture was cooled, concentrated to one quarter volume and poured into stirring acetonitrile (200 mL) to give a precipitate. The precipitate was filtered and dried under vacuum to provide 6-(5-amidino-1H-benzimidazol-2-yl)pyridine-3-carboxylic acid (1.4 g, 5.0 mmol). 1H-NMR (300 Mhz, DMSO-d6): 7.7 (m, 2H), 8.2 (s, 1H), 8.5 (m, 2H), 9.2 (s, 1H), 9.3 (s, 2H) 9.5 (s, 2H); MS (ESI), Calculated for C14H11N5O2 : 281.3, Found (MH+): 281.9.

Provenance & Evidence