HCID 178513218, compound → HCID 22125572, compound

Participants

Reaction Steps

A mixture comprising 6-fluoro-N-hydroxy-2-pyridin-2-yl-1H-benzimidazole-5-carboxamidine trifluoroacetate (108 mg, 0.4 mmol), Zn (55 mg, 1.2 mmol) and acetic acid (5 mL) was heated at reflux under nitrogen for 2 hours. The mixture was filtered and concentrated to dryness. The residue was taken up and purified by preparative reverse phase HPLC. The combined pure fractions were lyophilized to provide 6-fluoro-2-pyridin-2-yl-1H-benzimidazole-5-carboxamidine; MS (ESI), Calculated for C13H10FN5 : 255.09, Found (MH+): 255.9; 1H-NMR (300 Mhz, DMSO-d6): 7.64-7.69 (m, 2H), 7.97 (d, 1H), 8.08 (m, 1H), 8.42 (d, 1H), 8.78 (d, 1H), 8.48 (d, 4H).

Provenance & Evidence