Water → HCID 22125744, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4,5-dimethoxy-2-nitrophenyl)butanoic acid (4.75 g) and thiophenol (2 g) in N,N-dimethylformamide (40 ml) was added NaH dispersion (1.1 g, 80% NaH in mineral oil). The mixture was stirred under nitrogen at 140-150° C. for three hours, poured into cold water and acidified. The solid was filtered, washed with water and dried under vacuum. Finally, the product was triturated with diethyl ether. Yield: 3.37 g.

Provenance & Evidence