Methyl 4-ethynylbenzoate → HCID 54532048, compound

HRID 1858050Notes

Reaction equation

HRID 1858050 reaction equation
I/[CH:2]=[CH:3]/[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1.[C:18]([C:20]1[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=1)#[CH:19]>>[CH3:10][C:8]1[CH:7]=[CH:6][C:5]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[C:4]([CH:3]=[CH:2][C:19]#[C:18][C:20]2[CH:29]=[CH:28][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 640163Methyl 4-ethynylbenzoateHCID 22125925HCID 22125925, compound

Product 1

HCID 54532048HCID 54532048, compoundYield 10.4%

Procedure

In a similar manner to that of Example 1(e), by reaction of 4.00 g (12.0 mmol) of 2-((E)-2-iodovinyl)-4,4'-dimethylbiphenyl obtained in Example 12(f) with 1.74 g (10.9 mmol) of methyl 4-ethynylbenzoate, 400 mg (10%) of the expected compound are obtained in the form of yellow flakes with a melting point of 95-97° C.

Sources & evidence

ORD record
ord-199b6f8ab6004cf49c7950b6e5417099
Source dataset
uspto-grants-2000_11
Patent number
US06150413

Reaction notes

Loading…