Methyl 4-ethynylbenzoate → HCID 54179556, compound

HRID 1858052Notes

Reaction equation

HRID 1858052 reaction equation
I[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[CH:11]=1.[C:17]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1)#[CH:18]>>[CH3:16][C:12]1[CH:11]=[C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2][C:18]#[C:17][C:19]2[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=2)[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 640163Methyl 4-ethynylbenzoateHCID 53827264HCID 53827264, compound

Product 1

HCID 54179556HCID 54179556, compoundYield 23.5%

Procedure

In a similar manner to that of Example 1(e), by reaction of 2.10 g (6.55 mmol) of 2-(2-iodovinyl)-3'-methylbiphenyl obtained in Example 21(b) with 1.05 g (6.55 mmol) of methyl 4-ethynylbenzoate, 520 mg (22%) of the expected compound are obtained in the form of a yellow oil.

Sources & evidence

ORD record
ord-71bbd6351ecf42c9a70d097545451ac9
Source dataset
uspto-grants-2000_11
Patent number
US06150413

Reaction notes

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