Aminoacetaldehyde dimethyl acetal → N-(2,2-dimethoxyethyl)-2-Pyrazinamine

Participants

Reaction Steps

To a solution of 2-chloropiperazine (1.0 g in 5 mL dry toluene) was added 2,2-dimethoxyethylamine (1.1 g) followed by 1.2 mL triethylamine and the mixture heated to reflux on an oil bath. After 48 hours, the reaction mixture was applied to a flash chromatography column (silica gel) for purification (ethyl acetate:hexane, 7:3; then 100:0) to give the title compound (101 mg).

Provenance & Evidence