反应详情

温度

100 °C

To a suspension of 4-chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester (2.39 g in 12 mL N,N-dimethylformamide) and 0.183 g bis(triphenylphosphine)palladium(II) chloride was added 2.02 mL allyltin and the mixture heated to 100° C. on an oil bath. After 2 hours, the mixture was cooled, partitioned between ethyl acetate and water and the organic layer washed further with brine. Concentration of the dried (magnesium sulfate) organics and purification by flash chromatography on silica gel (hexane:ethyl acetate, 95:5; then 90:10) gave the title compound (1.4 g).

1. temperaturethe mixture was cooled
2. custompartitioned between ethyl acetate and water
3. washthe organic layer washed further with brine
4. dry with materialConcentration of the dried (magnesium sulfate) organics
5. custompurification by flash chromatography on silica gel (hexane