Pyrrolidine → HCID 53834865, compound

Participants

Reaction Steps

To a solution of 4-[2-(1-tert-butoxycarbonyl-piperidin-2-yl)-ethoxy]-7-chloro-3-(3,5-dimethylphenyl)-2-oxo-1,2-dihydro-quinoline-6-carboxylic acid (15 mg in 0.6 mL of dry methylene chloride) was added 8.0 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) followed by 6.0 mg 1-hydroxybenzotriazole (HOBt) and the mixture stirred for 10 minutes. At this time, 9.4 mg of pyrrolidine and the reaction allowed to proceed at room temperature. After 4 hours, the mixture was concentrated in vacuo and purified by flash chromatography on silica gel (methylene chloride:10% ammonium hydroxide in methanol, 95:5) to give the tilte compound (8 mg).

Provenance & Evidence