Aluminium lithium hydride → HCID 54358133, compound

Participants

Reaction Steps

To a solution of 2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-(methoxy-methylcarbamoyl)-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester (1.18 g in dry tetrahydrofuran) was added 3.9 mL of a 1M solution of lithium aluminum hydride and the mixture stirred at room temperature. After 2 hours, the reaction was quenched by the addition of saturated ammonium chloride solution. The mixture was filtered through diatomaceous earth and the filtrate extracted with ethyl acetate. The organics were then dried over magnesium sulfate and concentrated in vacuo to give the crude title compound (900 mg).

Provenance & Evidence