Aluminium lithium hydride → HCID 54155431, compound

Participants

Reaction Steps

To a solution of 2-{2-[7-chloro-3-(3,5-dimethylphenyl)-2-oxo-6-(pyrimidin-4-yliminomethyl)-1,2-dihydroquinolin-4-yloxy]-ethyl )-piperidine-1-carboxylic acid tert-butyl ester (36 mg in 2 mL dry tetrahydrofuran) at -10° C. was added a 1M solution of lithium aluminum hydride (2 mL) and the mixture stirred at low temperature. After 2 hours, the reaction was quenched by the addition of water, filtered and the organic portion concentrated in vacuo. Purification by preparative tic on silica gel gave the title compound.(12 mg).

Provenance & Evidence