Trifluoroacetic acid → HCID 22124516, compound

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Reaction Steps

To a solution of 2-(2-[7-chloro-3-(3,5-dimethylphenyl)-2-oxo-6-pyridin-2-yl-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester in 2.0 dry methylene chloride was added a few drops of anisole followed by 2.0 mL of trifluoroacetic acid and the mixture stirred at room temperature. After 1.5 hours, the solvents were removed in vacuo and the resulting residue purified by reverse-phase mplc (C-8, methanol:0.1% aqueous trifluoroacetic acid, 55:45) to give the title compound (112 mg). MASS: 488 (M+H)

Provenance & Evidence