HCID 15491456, compound → 3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Participants

Reaction Steps

A suspension of 1 gm (3.15 mMol) 1-hydroxy-5-amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[3,2-b]pyridine (H) dihydrochloride and 0.20 gm 10% palladium on carbon in 10 mL demineralized water was hydrogenated at ambient temperature with an initial hydrogen pressure of 45 p.s.i. After four hours the reaction mixture was filtered and the filtrate treated with 6 mL 2N aqueous sodium hydroxide. After the addition of 0.2 mL tetrahydrofuran the reaction mixture was stirred for 3 hours and the resulting precipitate collected by filtration. The solid was dried under reduced pressure at 50° C. to provide 0.59 gm (94%) of the title compound.

Provenance & Evidence