Trifluoroacetic acid → HCID 54571029, compound

Participants

Reaction Steps

To a solution of 2-{2-[7-chloro-3-(5-chlorothiophen-2-yl)-2-oxo-6-(pyrimidin-4-ylcarbamoyl)-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester (17 mg in 1.0 dry methylene chloride) was added a few drops of anisole followed by 0.5 mL of trifluoroacetic acid and the mixture stirred at room temperature. After 0.5 hours, the solvents were removed in vacuo and the resulting residue purified flash chromatography on silica gel (methylene chloride:methanol, 97:3+1% ammonium hydroxide; then 95:5+1% ammonium hydroxide; then 90:10+1% ammonium hydroxide) to give the title compound (9.6 mg). MASS: 545 (M+H)

Provenance & Evidence