Ethyl 4-nitrophenylacetate → p-Aminophenylacetic acid ethyl ester

Participants

Reaction Steps

A solution of 1 g (4.78 mmol) of ethyl-4-nitrophenylacetate in 10 ml of dry methanol was treated with 100 mg of 10% palladium-on-carbon and then hydrogenated at room temperature and at atmospheric pressure for 4 hours. The catalyst was removed by filtration and the filtrate was evaporated to give 830 mg (97%) of ethyl 4-aminophenylacetate as a mobile yellow oil.

Provenance & Evidence